ATP and adenosine receptors modulate IL-1β secretion during Porphyromonas gingivalis infection

Porphyromonas gingivalis (P. gingivalis) is a Gram-negative bacterium strongly associated with periodontitis. This pathogen induces pro- interleukin (IL)-1β synthesis by infected cells, but requires ligation of the P2X7 receptor by extracellular ATP (eATP) to trigger IL-1β release through NLRP3 inflammasome. We already demonstrated that eATP-induced IL- 1β secretion is impaired by P. gingivalis fimbriae via P2X7 receptor in macrophages. Here, we examined the effect of the activation of the purinergic signaling modulating IL-1β production during infection in macrophages