Add to ORKGTHESIS 11177Tumour-initiating cells are known to share some properties with stem cells. These so called \u27Cancer Stem Cells\u27 (CSCs) are highly tumourigenic in the undifferentiated state, a property that is lost upon CSC differentiation. For many years, our group has studied CSC differentiation in a nullipotent embryonal carcinoma CSC cell line (2102Ep), which can resist differentiation to produce highly-aggressive tumours. Previous work in the lab highlighted a potential role for Toll-Like Receptor (TLR) Signaling mediator protein Myeloid Differentiation Response Gene 88 (MyD88) in the mechanism through which 2102Ep cells resist differentiation
<div><p>MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically activ...
Cancer stem cells (CSCs) are a specific subpopulation of tumor cells that selectively possess tumor ...
To date two questions that remain unanswered regarding cancer are the following: i) how is it initia...
We have previously reported that myeloid differentiation primary response gene 88 (MyD88) is downreg...
Previous data obtained in our laboratory suggested that there may be constitutive signaling through ...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
Currently, many studies suggest that cancer stem cells (CSCs) are responsible for tumor initiation, ...
The mechanisms that link inflammatory responses to cancer development remain a subject of intense in...
Cancer stem cells/initiating cells (CSC/CIC), are thought to exist as a small population in malignan...
The cancer stem cell (CSC) model of carcinogenesis and progression posits that within a tumor lies a...
Cancer has long been considered as a heterogeneous population of uncontrolled proliferation of diffe...
Recent studies suggest that clear cell renal cell carcinoma (ccRCC) possesses a rare population of c...
Radiation therapy induces immunogenic cell death in cancer cells, whereby released endogenous adjuva...
Radiation therapy induces immunogenic cell death in cancer cells, whereby released endogenous adjuva...
<div><p>MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically activ...
Cancer stem cells (CSCs) are a specific subpopulation of tumor cells that selectively possess tumor ...
To date two questions that remain unanswered regarding cancer are the following: i) how is it initia...
We have previously reported that myeloid differentiation primary response gene 88 (MyD88) is downreg...
Previous data obtained in our laboratory suggested that there may be constitutive signaling through ...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
Currently, many studies suggest that cancer stem cells (CSCs) are responsible for tumor initiation, ...
The mechanisms that link inflammatory responses to cancer development remain a subject of intense in...
Cancer stem cells/initiating cells (CSC/CIC), are thought to exist as a small population in malignan...
The cancer stem cell (CSC) model of carcinogenesis and progression posits that within a tumor lies a...
Cancer has long been considered as a heterogeneous population of uncontrolled proliferation of diffe...
Recent studies suggest that clear cell renal cell carcinoma (ccRCC) possesses a rare population of c...
Radiation therapy induces immunogenic cell death in cancer cells, whereby released endogenous adjuva...
Radiation therapy induces immunogenic cell death in cancer cells, whereby released endogenous adjuva...
<div><p>MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically activ...
Cancer stem cells (CSCs) are a specific subpopulation of tumor cells that selectively possess tumor ...
To date two questions that remain unanswered regarding cancer are the following: i) how is it initia...