Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1.
- Sibon, David
- Cassar, Olivier
- Duga, Isabelle
- Brouzes, Chantal
- Ghez, David
- Pasquier, Christophe
- Sibon, Claire
- Desrames, Alexandra
- Mortreux, Franck
- Wattel, Eric
- Bazarbachi, Ali
- Gessain, Antoine
- Hermine, Olivier
DOIAbstract
International audienceAdult T-cell leukemia/lymphoma (ATLL), a T-cell neoplasm caused by human T-cell lymphotropic virus type 1 (HTLV-1), develops in the majority of cases in individuals who were infected with HTLV-1 as young children, by their mother during prolonged breastfeeding. We report the case of a Caucasian French man, whose parents were HTLV-1-seronegative and who developed ATLL after HTLV-1 sexual transmission by a Cameroonian woman. This hypothesis was corroborated by genotyping of the patient's virus, which revealed an HTLV-1B strain, found only in Central Africa, especially in Cameroon. Thus, ATLL may develop after HTLV-1 infection during adulthood, outside breastfeeding
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