Caspase-8 is the initiator caspase of extrinsic apoptosis(1,2) and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality(3), which can be rescued by deletion of either Ripk3 or Mlkl(4-6). Here we show that the expression of enzymatically inactive CASP8(C362S) causes embryonic lethality in mice by inducing necroptosis and pyroptosis. Similar to Casp8(-/-) mice(3,7), Casp8(C362S/C362S) mouse embryos died after endothelial cell necroptosis leading to cardiovascular defects. MLKL deficiency rescued the cardiovascular phenotype but unexpectedly caused perinatal lethality in Casp8(C362S/C362S) mice, indicating that CASP8(C362S) causes necroptosis-independent death at later stages of ...
Under stress conditions, cells in living tissue die by apoptosis or necrosis depending on the activa...
AbstractHomozygous targeted disruption of the mouse Caspase 8 (Casp8) gene was found to be lethal in...
SummaryCaspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter mole...
Caspase-8 is the initiator caspase of extrinsic apoptosis(1,2) and inhibits necroptosis mediated by ...
Caspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter molecule, F...
Caspase-8 is an apical component of cell death pathways. Activated caspase-8 can drive classical cas...
Caspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic lethality i...
CASPASE 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and proce...
SummaryCaspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic leth...
Caspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and proce...
Apoptosis is a caspase-dependent programmed form of cell death, which is commonly believed to be an ...
BACKGROUND AIMS: Disruption of the nuclear factor-?B (NF-?B) essential modulator (NEMO) in hepatocyt...
Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. C...
Knockout of caspase-8, a cysteine protease that participates in the signaling for cell death by rece...
Homozygous targeted disruption of the mouse Caspase 8 (Casp8) gene was found to be lethal in utero. ...
Under stress conditions, cells in living tissue die by apoptosis or necrosis depending on the activa...
AbstractHomozygous targeted disruption of the mouse Caspase 8 (Casp8) gene was found to be lethal in...
SummaryCaspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter mole...
Caspase-8 is the initiator caspase of extrinsic apoptosis(1,2) and inhibits necroptosis mediated by ...
Caspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter molecule, F...
Caspase-8 is an apical component of cell death pathways. Activated caspase-8 can drive classical cas...
Caspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic lethality i...
CASPASE 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and proce...
SummaryCaspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic leth...
Caspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and proce...
Apoptosis is a caspase-dependent programmed form of cell death, which is commonly believed to be an ...
BACKGROUND AIMS: Disruption of the nuclear factor-?B (NF-?B) essential modulator (NEMO) in hepatocyt...
Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. C...
Knockout of caspase-8, a cysteine protease that participates in the signaling for cell death by rece...
Homozygous targeted disruption of the mouse Caspase 8 (Casp8) gene was found to be lethal in utero. ...
Under stress conditions, cells in living tissue die by apoptosis or necrosis depending on the activa...
AbstractHomozygous targeted disruption of the mouse Caspase 8 (Casp8) gene was found to be lethal in...
SummaryCaspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter mole...