In the last decades, the number of patients undergoing pain relief for chronic or degenerative diseases has observed a significant increase, also due to an increase in the average age of the population. Morphine, the widely used opioid in pain therapy, is known to produce over time tolerance with the appearance of hyperalgesia and allodynia, conditions which may affect patient compliance. These phenomena have been re-conducted to one of its metabolite, the 3-O-glucuronide (accounting in humans for 80% of the dose administered), which was found to be an effective neuro-excitatory and a potent activator of microglia, so resulting to be responsible of the development of both hyperalgesia and allodynia. Therefore, the inhibition of glucuronidat...
We have previously found that phenantrenic opioids, such as heroin or naltrexone, modulate morphine ...
Pain constitutes a major public-health problem, and efficient pain control is a therapeutic priority...
A series of 14-substituted codeine derivatives were prepared for pharmacological study by sodium bor...
We have previously found that phenanthrenic opioids, including codeine, modulate morphine glucuronid...
It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expens...
textA series of morphinan-based compounds inspired by the semi-synthetic opioid metopon have been sy...
Opioids are well-known pain relievers and one of several therapeutic options for pain management. Al...
text(-) Codeine, (-) morphine, and their semi-synthetic derivatives play an integral role in medicin...
Sustained analgesia is crucial for patients suffering from long-acting pain. Ester derivatives of mo...
The present thesis describes our latest results in the chemistry of morphine alkaloids. An enantiodi...
Derivatives of Diels-Alder adducts of thebaine and of 14-hydroxy codeinone provide some of the most ...
The object of this review is to summarize the efforts which resulted in the discovery of therapeutic...
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissus da...
The present thesis describes our latest results in the chemistry of morphine alkaloids. An enantiod...
Derivatives of both 14-hydroxycodeinone and the Diels-Alder adducts of thebaine provide some of the ...
We have previously found that phenantrenic opioids, such as heroin or naltrexone, modulate morphine ...
Pain constitutes a major public-health problem, and efficient pain control is a therapeutic priority...
A series of 14-substituted codeine derivatives were prepared for pharmacological study by sodium bor...
We have previously found that phenanthrenic opioids, including codeine, modulate morphine glucuronid...
It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expens...
textA series of morphinan-based compounds inspired by the semi-synthetic opioid metopon have been sy...
Opioids are well-known pain relievers and one of several therapeutic options for pain management. Al...
text(-) Codeine, (-) morphine, and their semi-synthetic derivatives play an integral role in medicin...
Sustained analgesia is crucial for patients suffering from long-acting pain. Ester derivatives of mo...
The present thesis describes our latest results in the chemistry of morphine alkaloids. An enantiodi...
Derivatives of Diels-Alder adducts of thebaine and of 14-hydroxy codeinone provide some of the most ...
The object of this review is to summarize the efforts which resulted in the discovery of therapeutic...
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissus da...
The present thesis describes our latest results in the chemistry of morphine alkaloids. An enantiod...
Derivatives of both 14-hydroxycodeinone and the Diels-Alder adducts of thebaine provide some of the ...
We have previously found that phenantrenic opioids, such as heroin or naltrexone, modulate morphine ...
Pain constitutes a major public-health problem, and efficient pain control is a therapeutic priority...
A series of 14-substituted codeine derivatives were prepared for pharmacological study by sodium bor...