Synthesis, characterization and antibacterial activity of new triphenyl gathered dihydro pyrazoles

New triphenyl gathered pyrazoles were synthesized in two-step reaction via chalcone route. The first step is the synthesis of chalcones by the reaction of acetophenone and substituted aromatic aldehydes in the presence of sodium hydroxide in water-ethanol mixture. The second step is the reaction of chalcones and phenyl hydrazine in absolute alcohol gave triphenyl gathered pyrazoles (3a-h). The synthesized compounds were screened for their antibacterial activity. It is noteworthy that compounds 3a and 3h possessed dominant antibacterial capacity than standard because of presence of p-thiomethyl and p-nitro moiety on 5-substituted phenyl ring at para position against E. coli and S. aureus respectively. The structure of the synthesized triphenyl gathered pyrazoles (3a-h) were confirmed by spectral and elemental analysis data