Dielectric characterization of healthy and malignant colon tissues in the 0.5 18 GHz frequency band

Several reports over the last few decades have shown that the dielectric properties of healthy and malignant tissues of the same body organ usually show different values. However, no intensive dielectric studies of human colon tissue have been performed, despite colon cancer's being one of the most common types of cancer in the world. In order to provide information regarding this matter, a dielectric characterization of healthy and malignant colon tissues is presented. Measurements are performed on ex vivo surgery samples obtained from 20 patients, using an open-ended coaxial probe in the 0.5 18 GHz frequency band. Results show that the dielectric constant of colon cancerous tissue is 8.8% higher than that of healthy tissues (p = 0.002). Besides, conductivity is about 10.6% higher, but in this case measurements do not have statistical significance (p = 0.038). Performing an analysis per patient, the differences in dielectric constant between healthy and malignant tissues appear systematically. Particularized results for specific frequencies (500 MHz, 900 MHz, 2.45 GHz, 5 GHz, 8.5 GHz and 15 GHz) are also reported. The findings have potential application in early-stage cancer detection and diagnosis, and can be useful in developing new tools for hyperthermia treatments as well as creating electromagnetic models of healthy and cancerous tissues.The authors would like to thank the medical staff of the endoscopy unit of Hospital Universitari i Politecnic La Fe for their assistance in the gathering of tissue samples. This work was supported by Ministerio de Economia y Competitividad, Spain (ref. TEC2014-60258-C2-1-R, TEC2014-56469-REDT), by FEDER funds, and by a UPV-IISLaFe action (CEI-2G, 2014).Fornés Leal, A.; García Pardo, C.; Frasson, M.; Pons Beltrán, V.; Cardona Marcet, N. (2016). Dielectric characterization of healthy and malignant colon tissues in the 0.5 18 GHz frequency band. Physics in Medicine and Biology. 61(20):7334-7346. https://doi.org/10.1088/0031-9155/61/20/733473347346612