Neutral 1,3-Diindolylureas for Nerve Agent Remediation

Efficient neutralization of nerve-agent simulants by 1,3-diindolylureas in a neutral medium was investigated (DCP=diethylchlorophosphate, DCNP=diethylcyanophosphonate). The rate of hydrolysis of the simulants was found to increase by as much as 45¿% in the presence of these compounds. A mechanism based on the simulant complexation was established.DGICYT (projects MAT2009-14564-C04-1 and MAT2009-14564-C04-3) and GeneralitatValenciana (project PROMETEO/2009/016) are gratefully acknowledged. A. B. B. thanks MICINN for a pre-doctoral FPI fellowship. SCSIE (Universidad de Valencia) is gratefully acknowledged for all the equipment employed. PAG thanks the University of Southampton for a post-doctoral fellowship (JRH).Barba Bon, A.; Costero Nieto, AM.; Parra Álvarez, M.; Gil Grau, S.; Martínez Mañez, R.; Sancenón Galarza, F.; Gale, PA.... (2013). Neutral 1,3-Diindolylureas for Nerve Agent Remediation. 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