Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat-shock protein (Hsp)70-dependent manner. This liquid-liquid phase separation (LLPS)-mediated nuclear quality control mechanism is perturbed during neurodegeneration
The formation of membraneless organelles (MLOs) by phase separation has emerged as a new way of orga...
Protein- and RNA-containing foci and aggregates are a hallmark of many age- and mutation-related neu...
The integrity of the nuclear envelope depends on the function of nuclear pore complexes (NPCs), tran...
The nuclear proteome is rich in stress-sensitive proteins, which suggests that effective protein qua...
A new study reports an unexpected function of the nucleolus as a protein quality control compartment...
We uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelle...
Nuclear protein aggregation has been linked to genome instability and disease. The main source of ag...
In their natural environment, cells are regularly exposed to various stress conditions that may lead...
Contains fulltext : 212277.pdf (publisher's version ) (Open Access
We uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelle...
Nuclear protein aggregation has been linked to genome instability and disease. The main source of ag...
The formation of membraneless organelles (MLOs) by phase separation has emerged as a new way of orga...
Liquid-liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlyi...
The nuclear envelope (NE) is the defining feature of eukaryotic cells, separating the nucleus from t...
Subcellular compartmentalization allows the organization of complex biochemical reactions in space a...
The formation of membraneless organelles (MLOs) by phase separation has emerged as a new way of orga...
Protein- and RNA-containing foci and aggregates are a hallmark of many age- and mutation-related neu...
The integrity of the nuclear envelope depends on the function of nuclear pore complexes (NPCs), tran...
The nuclear proteome is rich in stress-sensitive proteins, which suggests that effective protein qua...
A new study reports an unexpected function of the nucleolus as a protein quality control compartment...
We uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelle...
Nuclear protein aggregation has been linked to genome instability and disease. The main source of ag...
In their natural environment, cells are regularly exposed to various stress conditions that may lead...
Contains fulltext : 212277.pdf (publisher's version ) (Open Access
We uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelle...
Nuclear protein aggregation has been linked to genome instability and disease. The main source of ag...
The formation of membraneless organelles (MLOs) by phase separation has emerged as a new way of orga...
Liquid-liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlyi...
The nuclear envelope (NE) is the defining feature of eukaryotic cells, separating the nucleus from t...
Subcellular compartmentalization allows the organization of complex biochemical reactions in space a...
The formation of membraneless organelles (MLOs) by phase separation has emerged as a new way of orga...
Protein- and RNA-containing foci and aggregates are a hallmark of many age- and mutation-related neu...
The integrity of the nuclear envelope depends on the function of nuclear pore complexes (NPCs), tran...
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