Glycogen synthase kinase 3beta (GSK3beta) is involved in metabolism, neurodegeneration, and cancer. Inhibition of GSK3beta activity is the primary mechanism that regulates this widely expressed active kinase. Although the protein kinase Akt inhibits GSK3beta by phosphorylation at the N terminus, preventing Akt-mediated phosphorylation does not affect the cell-survival pathway activated through the GSK3beta substrate beta-catenin. Here, we show that p38 mitogen-activated protein kinase (MAPK) also inactivates GSK3beta by direct phosphorylation at its C terminus, and this inactivation can lead to an accumulation of beta-catenin. p38 MAPK-mediated phosphorylation of GSK3beta occurs primarily in the brain and thymocytes. Activation of beta-cate...
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates in an array of cri...
The development of diabetes mellitus depends on the balance between beta-cell proliferation and deat...
Increased anaerobic glycolysis is a common feature of many cancer cells, which have adapted their me...
Glycogen synthase kinase 3beta (GSK3beta) is involved in metabolism, neurodegeneration, and cancer. ...
p38δ mitogen activated protein kinase (MAPK) is a unique stress responsive protein kinase. While the...
Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of ...
Summaryp38 mitogen-activated protein kinases (MAPK) are a family of Ser/Thr kinases that regulate im...
Identified originally as a regulator of glycogen metabolism, glycogen synthase kinase-3 (GSK3) is no...
The inhibition of Glycogen Synthase Kinase 3 β (GSK3β) by Ser9 phosphorylation affects many physiolo...
Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, ar...
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kin...
<div><p>Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct g...
We have recently reported that mitogen-activated protein kinase (MAPK) JNK1 downregulates beta-caten...
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates in an array of cri...
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates in an array of cri...
The development of diabetes mellitus depends on the balance between beta-cell proliferation and deat...
Increased anaerobic glycolysis is a common feature of many cancer cells, which have adapted their me...
Glycogen synthase kinase 3beta (GSK3beta) is involved in metabolism, neurodegeneration, and cancer. ...
p38δ mitogen activated protein kinase (MAPK) is a unique stress responsive protein kinase. While the...
Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of ...
Summaryp38 mitogen-activated protein kinases (MAPK) are a family of Ser/Thr kinases that regulate im...
Identified originally as a regulator of glycogen metabolism, glycogen synthase kinase-3 (GSK3) is no...
The inhibition of Glycogen Synthase Kinase 3 β (GSK3β) by Ser9 phosphorylation affects many physiolo...
Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, ar...
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kin...
<div><p>Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct g...
We have recently reported that mitogen-activated protein kinase (MAPK) JNK1 downregulates beta-caten...
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates in an array of cri...
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates in an array of cri...
The development of diabetes mellitus depends on the balance between beta-cell proliferation and deat...
Increased anaerobic glycolysis is a common feature of many cancer cells, which have adapted their me...