We have previously demonstrated that a novel protein ZYG1 induces sexual cell fusion (zygote formation) of Dictyostelium cells. In the process of cell fusion, involvements of signal transduction pathways via Ca2+ and PKC (protein kinase C) have been suggested because zygote formation is greatly enhanced by PKC activators. In fact, there are several deduced sites phosphorylated by PKC in ZYG1 protein. Thereupon, we designed the present work to examine whether or not ZYG1 is actually phosphorylated by PKC and localized at the regions of cell-cell contacts where cell fusion occurs. These were ascertained, suggesting that ZYG1 might be the target protein for PKC. A humanized version of zyg1 cDNA (mzyg1) was introduced into myoblasts to know if ...
Protein kinase C (PKC) is an atypical member of the PKC family of serine/threonine kinases with hig...
Trophoblastic cell-cell fusion is an essential event required during human placental development. Se...
In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, ther...
The fusion of mammalian cells into syncytia is a developmental process that is tightly restricted to...
International audienceCell fusion occurs as part of the differentiation of some cell types, includin...
Cell fusion is universal in eukaryotes for fertilization and development, but what signals this proc...
AbstractCell–cell fusion is a highly regulated and dramatic cellular event that is required for deve...
Cell-cell fusion is a ubiquitous process that underlies fertilization and development of eukaryotes....
The cellular slime mold, Dictyostelium mucoroides-7 (Dm7) exhibits clear dimorphism; macrocyst forma...
The syncytiotrophoblast of the human placenta is an epithelial barrier that interacts with maternal ...
International audienceA limited number of human cells can fuse to form multinucleated syncytia. In t...
FGFRL1 is a single-pass transmembrane protein with three extracellular Ig domains. When overexpresse...
PKC3 mediates the signal transduction response to a wide variety of growth factors, hormones, and ne...
Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but li...
(IF : 4,23)International audienceTrophoblastic cell-cell fusion is an essential event required durin...
Protein kinase C (PKC) is an atypical member of the PKC family of serine/threonine kinases with hig...
Trophoblastic cell-cell fusion is an essential event required during human placental development. Se...
In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, ther...
The fusion of mammalian cells into syncytia is a developmental process that is tightly restricted to...
International audienceCell fusion occurs as part of the differentiation of some cell types, includin...
Cell fusion is universal in eukaryotes for fertilization and development, but what signals this proc...
AbstractCell–cell fusion is a highly regulated and dramatic cellular event that is required for deve...
Cell-cell fusion is a ubiquitous process that underlies fertilization and development of eukaryotes....
The cellular slime mold, Dictyostelium mucoroides-7 (Dm7) exhibits clear dimorphism; macrocyst forma...
The syncytiotrophoblast of the human placenta is an epithelial barrier that interacts with maternal ...
International audienceA limited number of human cells can fuse to form multinucleated syncytia. In t...
FGFRL1 is a single-pass transmembrane protein with three extracellular Ig domains. When overexpresse...
PKC3 mediates the signal transduction response to a wide variety of growth factors, hormones, and ne...
Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but li...
(IF : 4,23)International audienceTrophoblastic cell-cell fusion is an essential event required durin...
Protein kinase C (PKC) is an atypical member of the PKC family of serine/threonine kinases with hig...
Trophoblastic cell-cell fusion is an essential event required during human placental development. Se...
In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, ther...