We present here a comprehensive analysis of the complement of enzymes in a large variety of species. As enzymes are a relatively conserved group there are several classification systems available that are common to all species and link a protein sequence to an enzymatic function. Enzymes are therefore an ideal functional group to study the relationship between sequence expansion, functional divergence and phenotypic changes. By using information retrieved from the well annotated SWISS-PROT database together with sequence information from a variety of fully sequenced genomes and information from the EC functional scheme we have aimed here to estimate the fraction of enzymes in genomes, to determine the extent of their functional redundancy i...
The analysis of completely sequenced genomes uncovers an astonishing variability between species in ...
In order to identify common and specific enzymatic activities associated with the metabolism of the ...
AbstractThe availability of genome sequences and functional genomics data from multiple species enab...
Gene duplication is a crucial process involved in the appearance of new genes and functions. It is t...
<div><p>In order to understand the evolution of enzyme reactions and to gain an overview of biologic...
AbstractEnzymes, as biological catalysts, form the basis of all forms of life. How these proteins ha...
<div><p>In this work, the content of enzymes and DNA-binding transcription factors (TFs) in 794 non-...
Protein domains sometime combine to form multidomain proteins and are acquired or lost in lineages o...
Abstract Background Cellular metabolism is a fundamen...
Studying the evolution of enzymes and their functions improves our ability to determine the function...
AbstractEnzymes are the proteins responsible for the catalysis of life. Enzymes sharing a common anc...
The evolution of enzymes affects how well a species can adapt to new environmental conditions. Durin...
Multi-functional enzymes are enzymes that perform multiple physiological functions. Characterization...
AbstractThe functional composition of organisms can be analysed for the first time with the appearan...
In order to understand the evolution of enzyme reactions and to gain an overview of biological catal...
The analysis of completely sequenced genomes uncovers an astonishing variability between species in ...
In order to identify common and specific enzymatic activities associated with the metabolism of the ...
AbstractThe availability of genome sequences and functional genomics data from multiple species enab...
Gene duplication is a crucial process involved in the appearance of new genes and functions. It is t...
<div><p>In order to understand the evolution of enzyme reactions and to gain an overview of biologic...
AbstractEnzymes, as biological catalysts, form the basis of all forms of life. How these proteins ha...
<div><p>In this work, the content of enzymes and DNA-binding transcription factors (TFs) in 794 non-...
Protein domains sometime combine to form multidomain proteins and are acquired or lost in lineages o...
Abstract Background Cellular metabolism is a fundamen...
Studying the evolution of enzymes and their functions improves our ability to determine the function...
AbstractEnzymes are the proteins responsible for the catalysis of life. Enzymes sharing a common anc...
The evolution of enzymes affects how well a species can adapt to new environmental conditions. Durin...
Multi-functional enzymes are enzymes that perform multiple physiological functions. Characterization...
AbstractThe functional composition of organisms can be analysed for the first time with the appearan...
In order to understand the evolution of enzyme reactions and to gain an overview of biological catal...
The analysis of completely sequenced genomes uncovers an astonishing variability between species in ...
In order to identify common and specific enzymatic activities associated with the metabolism of the ...
AbstractThe availability of genome sequences and functional genomics data from multiple species enab...