Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease
- Anna Vašků
- Jaroslav Meluzín
- Jan Blahák
- Vladimír Kincl
- Monika Pávková Goldbergová
- Jan Sitar
- Filip Zlámal
- Julie Bienertová-Vašků
- Jiří Vítovec
Publication date
January 2012
DOI Publisher
IOS Press ISSN
0278-0240 Journal
Disease MarkersAbstract
Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity
Add to ORKG