Compelling data demonstrate that inflammation-associated anorexia directly results from the action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous system. For instance, the aforementioned pro-inflammatory factors can stimulate the activity of peripheral sensory neurons, and induce their own de novo synthesis and release into the brain parenchyma and cerebrospinal fluid. Ultimately, it results in the mobilization of a specific neural circuit that shuts down appetite. The present article describes the different cell groups and neurotransmitters involved in inflammation-associated anorexia and examines how they interact with neural systems regulating feeding such as the melanocortin system. A better under...
Under normal conditions, food intake is controlled in the hypothalamus by: (i) transducing metabolic...
Copyright © 2008 Elsevier Inc. All rights reserved.Cachexia or wasting disease occurs commonly in di...
Appetite is often reduced in patients with chronic illness, including cancer. Cancer anorexia, loss ...
International audienceObjectives: Infections, cancer, and systemic inflammation elicit anorexia. Des...
Anyone who has experienced influenza or a bacterial infection knows what it means to be ill. Apart f...
Loss of appetite is together with fever and malaise hallmarks of infection. Loosing appetite during ...
Anorexia and weight loss are prevalent in infectious diseases. To investigate the molecular mechanis...
Given the high-energy requirements to sustain immune responses and healing processes, it is intrigui...
Objectives: Infections, cancer, and systemic inflammation elicit anorexia. Despite the medical signi...
Under normal conditions, the homeostasis of energy intake is maintained in the hypothalamus by 1) tr...
<p>Background: Anorexia can occur as a serious complication of disease. Increasing evidence suggests...
Loss of appetite or anorexia associated with inflammation impairs quality of life and increases morb...
Whereas anorexia is a common behavioral response to infectious diseases, the reasons for and mechani...
Anorexia is part of the body's acute-phase response to illness. Microbial products such as lipopolys...
Systemic inflammation evokes an array of brain-mediated responses including fever, anorexia and tast...
Under normal conditions, food intake is controlled in the hypothalamus by: (i) transducing metabolic...
Copyright © 2008 Elsevier Inc. All rights reserved.Cachexia or wasting disease occurs commonly in di...
Appetite is often reduced in patients with chronic illness, including cancer. Cancer anorexia, loss ...
International audienceObjectives: Infections, cancer, and systemic inflammation elicit anorexia. Des...
Anyone who has experienced influenza or a bacterial infection knows what it means to be ill. Apart f...
Loss of appetite is together with fever and malaise hallmarks of infection. Loosing appetite during ...
Anorexia and weight loss are prevalent in infectious diseases. To investigate the molecular mechanis...
Given the high-energy requirements to sustain immune responses and healing processes, it is intrigui...
Objectives: Infections, cancer, and systemic inflammation elicit anorexia. Despite the medical signi...
Under normal conditions, the homeostasis of energy intake is maintained in the hypothalamus by 1) tr...
<p>Background: Anorexia can occur as a serious complication of disease. Increasing evidence suggests...
Loss of appetite or anorexia associated with inflammation impairs quality of life and increases morb...
Whereas anorexia is a common behavioral response to infectious diseases, the reasons for and mechani...
Anorexia is part of the body's acute-phase response to illness. Microbial products such as lipopolys...
Systemic inflammation evokes an array of brain-mediated responses including fever, anorexia and tast...
Under normal conditions, food intake is controlled in the hypothalamus by: (i) transducing metabolic...
Copyright © 2008 Elsevier Inc. All rights reserved.Cachexia or wasting disease occurs commonly in di...
Appetite is often reduced in patients with chronic illness, including cancer. Cancer anorexia, loss ...