Abstract Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein expression in AD is still elusive. Activated glia cells are shown to secrete substances that can induce expression of COX-2 and cell cycle proteins in vitro. Using post mortem brain tissue we have investigated whether activation of microglia and astrocytes in AD brain can be correlated with the expression of COX-2 and phosphorylated retinoblastoma protein (ppRb). The highest levels of neuronal COX-2 and ppRb immunoreactivity are observed in the first stages of AD pathology (Braak 0–II, Braak A). No significant difference in COX...
Alzheimer disease (AD) is the most prevalent cause of dementia in humans, and the symptoms are commo...
Classical immunohistochemical studies in the Alzheimer disease (AD) brain reveal prominent glial rea...
Abstract Background While multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are primar...
Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute t...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of beta amy...
Prostaglandins (PGs) are generated by the enzymatic activity of cyclooxygenase-1 and -2 (COX-1/2) an...
Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alz...
The pathogenesis of Alzheimer’s disease is complicated and related to COX-2. The NG108-15 cell line ...
Alzheimer's disease (AD) is characterized by the accumulation and aggregation of misfolded proteins....
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitot...
Non-steroidal anti-inflammatory drugs (NSAIDs) may decrease the risk of developing Alzheimer's disea...
Cyclooxygenases (cox) are potent mediators of inflamation and two cox-izoenzymes, cox-1, cox-2, are ...
The molecular mechanisms that regulate neuronal cell death in neurodegenerative diseases remain uncl...
Alzheimer's disease (AD) is an incurable neurodegenerative condition resulting in progressive cognit...
Background Alzheimer’s disease (AD) is the most common neurodegenerative disease. In addition to the...
Alzheimer disease (AD) is the most prevalent cause of dementia in humans, and the symptoms are commo...
Classical immunohistochemical studies in the Alzheimer disease (AD) brain reveal prominent glial rea...
Abstract Background While multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are primar...
Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute t...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of beta amy...
Prostaglandins (PGs) are generated by the enzymatic activity of cyclooxygenase-1 and -2 (COX-1/2) an...
Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alz...
The pathogenesis of Alzheimer’s disease is complicated and related to COX-2. The NG108-15 cell line ...
Alzheimer's disease (AD) is characterized by the accumulation and aggregation of misfolded proteins....
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitot...
Non-steroidal anti-inflammatory drugs (NSAIDs) may decrease the risk of developing Alzheimer's disea...
Cyclooxygenases (cox) are potent mediators of inflamation and two cox-izoenzymes, cox-1, cox-2, are ...
The molecular mechanisms that regulate neuronal cell death in neurodegenerative diseases remain uncl...
Alzheimer's disease (AD) is an incurable neurodegenerative condition resulting in progressive cognit...
Background Alzheimer’s disease (AD) is the most common neurodegenerative disease. In addition to the...
Alzheimer disease (AD) is the most prevalent cause of dementia in humans, and the symptoms are commo...
Classical immunohistochemical studies in the Alzheimer disease (AD) brain reveal prominent glial rea...
Abstract Background While multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are primar...