Abstract A recent study demonstrated that vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) activate Raf-1 kinase in an experimental neovasculature system. The study showed that bFGF and VEGF activate p21-activated protein kinase-1 (PAK-1) and Src kinase, respectively. PAK-1 and Src kinases phosphorylate specific serine and tyrosine residues within the activation loop of Raf-1 kinase. Their findings further suggest that phosphorylation at these sites protects endothelial cells from apoptosis induced by both intrinsic and extrinsic factors. The tumor neovasculature provides specific molecular markers or "zip codes". This group of investigators has previously shown that nanosphere-aided targeting of the neova...
Communication between diseased cells and the microenvironment is a complex yet crucial element in pr...
AbstractSmall molecule vascular endothelial growth factor (VEGF) receptor tyrosinase kinase inhibito...
Vascular targeting of malignant tissues with systemically injected nanoparticles (NPs) holds promise...
Efforts to influence the biology of blood vessels by gene delivery have been hampered by a lack of t...
Angiogenesis is known as one of the hallmarks of cancer. Multiple lines evidence indicated that vasc...
AbstractA mutant Raf-1 gene loaded onto nanoparticles, delivered to tumor vasculature with an integr...
Currently there is a high need for efficacious medicines in cancer therapy. The use of conventional ...
Two main strategies have been pursued for the development of an effective and targeted anti-cancer t...
Abstract Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging s...
ConspectusThe past decades have witnessed the development of a field dedicated to targeting tumor va...
The availability of nanoparticles (NPs) to deliver small interfering RNA (siRNA) has significantly e...
The tumour vasculature plays an important role in tumour growth and metastasis. Tumour angiogenesis ...
Therapeutic angiogenesis is an emerging paradigm for the management of ischemic pathologies. Proangi...
Angiogenesis is induced by an increase in pro-angiogenic factors in tissue microenvironments, which ...
The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report...
Communication between diseased cells and the microenvironment is a complex yet crucial element in pr...
AbstractSmall molecule vascular endothelial growth factor (VEGF) receptor tyrosinase kinase inhibito...
Vascular targeting of malignant tissues with systemically injected nanoparticles (NPs) holds promise...
Efforts to influence the biology of blood vessels by gene delivery have been hampered by a lack of t...
Angiogenesis is known as one of the hallmarks of cancer. Multiple lines evidence indicated that vasc...
AbstractA mutant Raf-1 gene loaded onto nanoparticles, delivered to tumor vasculature with an integr...
Currently there is a high need for efficacious medicines in cancer therapy. The use of conventional ...
Two main strategies have been pursued for the development of an effective and targeted anti-cancer t...
Abstract Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging s...
ConspectusThe past decades have witnessed the development of a field dedicated to targeting tumor va...
The availability of nanoparticles (NPs) to deliver small interfering RNA (siRNA) has significantly e...
The tumour vasculature plays an important role in tumour growth and metastasis. Tumour angiogenesis ...
Therapeutic angiogenesis is an emerging paradigm for the management of ischemic pathologies. Proangi...
Angiogenesis is induced by an increase in pro-angiogenic factors in tissue microenvironments, which ...
The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report...
Communication between diseased cells and the microenvironment is a complex yet crucial element in pr...
AbstractSmall molecule vascular endothelial growth factor (VEGF) receptor tyrosinase kinase inhibito...
Vascular targeting of malignant tissues with systemically injected nanoparticles (NPs) holds promise...