We examined the clonal evolution of skin malignant lesions by repeated topical applications of 20- methylcholanthrene (20-MC) to the skin, which induces hyperplastic epidermis, papillomatous lesion and invasive carcinoma in mice. The lesions were examined histologically and immunohistochemically with anti-single-stranded DNA after acid hydrolysis (DNA-instability test), p53, VEGF, DFF45, PCNA and AgNORs parameters analyses. Multiple clones with increased DNA instability comparable to that of invasive carcinoma were noted in early-stage (2-6 weeks) hyperplastic epidermis, and their number increased in middle (7-11 weeks), and late-stages (12-25 weeks) of hyperplastic epidermis, indicating that they belong to the malignancy category. All papi...
Regenerative epidermal hyperplasia produced by repeated abrasion every 21days of the skin of female ...
Topical application of dibenzo[a,l]pyrene (DB[a,l]P) to the dorsal skin of SENCAR mice induces codon...
In the field of chemical carcinogenesis the use of animal models has proved to be a useful tool in d...
We examined the clonal evolution of skin malig-nant lesions by repeated topical applications of 20-m...
To stimulate conditions wherein humans might be exposed to tumor promoters prior to carcinogenic sti...
Skin tumors chemically induced in mice have provided an important experimental model for studying ca...
Studies performed on mouse skin have indicated that chemical carcinogenesis can be subdivided into t...
We have conducted a series of experiments to characterize the lesions that are precursors of cutaneo...
Independent clones of mouse keratinocytes initiated in vitro gave rise to rumor phenotypes typical o...
Chemical carcinogen induction of skin tumors in mice was investigated to determine (i) if tumor indu...
Independent clones of mouse keratinocytes initiated in vitro gave rise to tumor phenotypes typical o...
'To whom all correspondence should be addressed The mouse skin tumor model was used to investig...
One of the important areas of investigation today concerning skin chemical carcinogenesis in mice is...
We have previously shown that the precursors of cutaneous papillomas in SENCAR mice initiated with 7...
Thesis (M.A.)--Boston UniversityThe histological and cytological changes occurring when the mouse ep...
Regenerative epidermal hyperplasia produced by repeated abrasion every 21days of the skin of female ...
Topical application of dibenzo[a,l]pyrene (DB[a,l]P) to the dorsal skin of SENCAR mice induces codon...
In the field of chemical carcinogenesis the use of animal models has proved to be a useful tool in d...
We examined the clonal evolution of skin malig-nant lesions by repeated topical applications of 20-m...
To stimulate conditions wherein humans might be exposed to tumor promoters prior to carcinogenic sti...
Skin tumors chemically induced in mice have provided an important experimental model for studying ca...
Studies performed on mouse skin have indicated that chemical carcinogenesis can be subdivided into t...
We have conducted a series of experiments to characterize the lesions that are precursors of cutaneo...
Independent clones of mouse keratinocytes initiated in vitro gave rise to rumor phenotypes typical o...
Chemical carcinogen induction of skin tumors in mice was investigated to determine (i) if tumor indu...
Independent clones of mouse keratinocytes initiated in vitro gave rise to tumor phenotypes typical o...
'To whom all correspondence should be addressed The mouse skin tumor model was used to investig...
One of the important areas of investigation today concerning skin chemical carcinogenesis in mice is...
We have previously shown that the precursors of cutaneous papillomas in SENCAR mice initiated with 7...
Thesis (M.A.)--Boston UniversityThe histological and cytological changes occurring when the mouse ep...
Regenerative epidermal hyperplasia produced by repeated abrasion every 21days of the skin of female ...
Topical application of dibenzo[a,l]pyrene (DB[a,l]P) to the dorsal skin of SENCAR mice induces codon...
In the field of chemical carcinogenesis the use of animal models has proved to be a useful tool in d...