International audienceRecent observations of sulfur oxides (SO2, SO, OCS, and H2SO4) in Venus’ mesosphere have generated controversy and great interest in the scientific community. These observations revealed unexpected spatial patterns and spatial/temporal variability that have not been satisfactorily explained by models. Particularly intriguing are the layer of enhanced gas- phase SO2 and SO in the upper mesosphere, and variability in the maximum observed SO2 abundance and the equator-to-pole SO2 abundance gradient, seemingly on multi-year cycles, that is not uniquely linked to local time variations. Sulfur oxide chemistry on Venus is closely linked to the global- scale cloud and haze layers, which are composed primarily of concentrated s...