Synthesis and Screening of some benzoxazinone derivatives

Benzoxazinone derivatives fused with other heterocyclic and aromatic ring system were reported to possess various activities such as anti-inflammatory, analgesic, antimicrobial. The Benzoxazinone are an important group of secondary metabolites occurring in gramineae, acanthaceae, and ranunculaceae. Novel 1, 4-benzoxazin-3-one derivative have been synthesized which would have inhibitory activities against tyrosine kinases and the inhibitory activities against KDR and ABL which are closely related to chronic disease such as cancer. 1,4- Benzoxazinones has wide application in medicinal chemistry due to its pharmacological properties. The members of this family are used for treating parkinsons disease, ischemia reperfusion, selective potassium channel openers, antinociceptive, antidepressant and anti-fungal agent. Keywords: Benzoxazinone, secondary metabolites, tyrosine kinases, bantinociceptive