Add to ORKGIn brain tumors, delivering nanoparticles across the blood-tumor barrier presents major hurdles. A clinically relevant MRI contrast agent, GdDOTA and a near-infrared (NIR) fluorescent dye, DL680 were conjugated to a G5 PAMAM dendrimer, thus producing a dual-mode MRI and NIR imaging agent. Systemic delivery of the subsequent nano-sized agent demonstrated glioma-specific accumulation, probably due to the enhanced permeability and retention effect
Chen Shen,1,2,* Xiaoxiong Wang,1,2,* Zhixing Zheng,1,2,* Chuang Gao,3 Xin Chen,1,2 Shiguang Zhao,1,2...
Bioimaging is a powerful tool for diagnosing tumors but remains limited in terms of sensitivity and ...
The poor permeability of theranostic agents across the blood-brain barrier (BBB) significantly hampe...
Dendritic polymers or dendrimers present an alternate template for the development of nanoparticulat...
Abstract Background Effective transvascular delivery of nanoparticle-based chemotherapeutics across ...
Surgical resection is a mainstay of brain tumor treatments. However, the completed excision of malig...
Novel therapeutic and diagnostic methods are sorely needed for gliomas, which contribute yearly to h...
There is no available targeted therapy or imaging agent for triple negative breast cancer (TNBC). We...
A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance...
Glioma is a general term used to describe the primary brain tumors that are the most common in the c...
International audiencePhotodynamic therapy (PDT) for brain tumors appears to be complementary to con...
Glioblastoma (GBM) is one of the most malignant tumors with poor prognosis and outcomes. Although sm...
The most common malignant tumor of the brain is glioblastoma multiforme (GBM) in adults. Many patien...
International audiencePhotodynamic therapy (PDT) for brain tumors appears to be complementary to con...
Brain tumours are heterogeneous and are classified comprehensively into molecular subtypes based on ...
Chen Shen,1,2,* Xiaoxiong Wang,1,2,* Zhixing Zheng,1,2,* Chuang Gao,3 Xin Chen,1,2 Shiguang Zhao,1,2...
Bioimaging is a powerful tool for diagnosing tumors but remains limited in terms of sensitivity and ...
The poor permeability of theranostic agents across the blood-brain barrier (BBB) significantly hampe...
Dendritic polymers or dendrimers present an alternate template for the development of nanoparticulat...
Abstract Background Effective transvascular delivery of nanoparticle-based chemotherapeutics across ...
Surgical resection is a mainstay of brain tumor treatments. However, the completed excision of malig...
Novel therapeutic and diagnostic methods are sorely needed for gliomas, which contribute yearly to h...
There is no available targeted therapy or imaging agent for triple negative breast cancer (TNBC). We...
A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance...
Glioma is a general term used to describe the primary brain tumors that are the most common in the c...
International audiencePhotodynamic therapy (PDT) for brain tumors appears to be complementary to con...
Glioblastoma (GBM) is one of the most malignant tumors with poor prognosis and outcomes. Although sm...
The most common malignant tumor of the brain is glioblastoma multiforme (GBM) in adults. Many patien...
International audiencePhotodynamic therapy (PDT) for brain tumors appears to be complementary to con...
Brain tumours are heterogeneous and are classified comprehensively into molecular subtypes based on ...
Chen Shen,1,2,* Xiaoxiong Wang,1,2,* Zhixing Zheng,1,2,* Chuang Gao,3 Xin Chen,1,2 Shiguang Zhao,1,2...
Bioimaging is a powerful tool for diagnosing tumors but remains limited in terms of sensitivity and ...
The poor permeability of theranostic agents across the blood-brain barrier (BBB) significantly hampe...