Glucose Phosphate Isomerase Deficiency: Unusual acute hemolytic crisis in a middle-aged woman

Hereditary hemolytic anemia associated with glucose phosphate isomerase (GPI) deficiency was first reported in 1967. Since then, about 30 cases have been reported in the literature; their ages ranged between 1 and 26 years. We present a case of glucose phosphate isomerase deficiency in a 56-year-old woman. Steroid therapy seemed to resolve our patient\u27s acute stage. Since it has not been mentioned previously, further evaluation is necessary. Consideration of this deficiency may be helpful in investigating hemolytic anemia, regardless of the patient\u27s age