Effectiveness of Boiled Figs Leaf (Ficus Carica L) Towards Ureum and Creatinin Serum of Male Wistar Strain Rats with Acute Renal Failure Model

Acute renal failure is a set of clinical symptoms characterized by increased levels ofcreatinine and blood urea nitrogen and a rapids decrease in the rate of glomerular filtration.The Objectives of this study was to determine the effectiveness of brewed tin water (FicusCarica L) against urea and creatinine serum of male Wistar strain rats in acute renal Failure.The subject of the research were 30 male rats weighing 180-200 grams and 2-3 months old,which were divided into 3 groups, namely the negative control group, the positive controlgroup and the treatment group. Each group consisted of 10 rats. The negative control groupwas only given food and drink as usual. The positive control group and the treatment groupwere induced with gentamicin 12 mg / intraperitonial for 7 days to increase urea andcreatinine serum levels. The treatment group was given steeping treatment of 0.65 grams ofboiled figs leaf in 100cc of given 3.6cc/orally for 7 days. One way ANOVA test wasconducted to analyse the study using SPSS version 24. The results found there are nosignificant differences in urea serum levels between the treatment group and negative controlgroup (p = 0.252) but there were significant differences in the urea serum value between thetreatment group and positive control group (p <0.05). There was a significant difference inthe value of creatinine serum between the treatment group, the positive control group and thenegative control group (p <0.05). As Conclusions boiled figs leaf (Ficus Carica L) has aneffect on decreasing urea and creatinine serum levels in male wistar rats with acute renalfailure