Effectiveness Rosy Periwinkle (Catharanthus roseus L.) Decoction Toward Urea and Creatinine Serum Levels of Male Wistar Strain Rats with Acute Kidney Failure Model

Acute kidney failure is a disorder that occurs suddenly in the ability of the kidneys toinfiltrate blood, which is characterized by increased levels of urea and creatinine within a fewhours or days. This study aims to determine the effectiveness of the Rosy Periwinkle (Catharanthus roseus L. ) on the levels of urea and creatinine in male Wistar Strain with acutekidney failure models. The object of the study were30 male Wistar Strain Rats aged 2-3months with a weight of 180-200 grams per rat. The study was divided into three groups,namely the treatment group, positive control group, and negative control group. Each groupconsists of 10 male rats. Tread leaves taken as much as 5.2 grams are boiled in 300 cc ofwater until the remaining 100 cc of boiled water. The treatment group and positive controlgroup induced gentamicin 12 mg in 0.3 cc intraperitoneal / rat / day for 7 days. The treatmentgroup was given boiled water for as much as 3.6 cc / day orally for 7 days. Giving agentamicin injection to damage the kidneys. Data collection on urea and creatinine levels wascalculated using the SPSS program version 24 One Way ANOVA test to compare creatinineurea levels. The results showed that there were significant differences in creatinine urealevels between the treatment group and the positive control group (p <0.05). The conclusionof this study is that the boiled water of Rosy Periwinkle ( Catharanthus roseus L. ) is effectivein reducing the level of urea and creatinine of male Wistar Strain Rats with acute kidneyfailure model