RATIONALE: Ventilator-induced diaphragm dysfunction (VIDD) increases morbidity and mortality in critical care patients. Although VIDD has been associated with mitochondrial oxidative stress and calcium homeostasis impairment, the underling mechanisms are still unknown. We hypothesized that diaphragmatic mitochondrial oxidative stress causes remodeling of the ryanodine receptor (RyR1)/calcium release channel, contributing to sarcoplasmic reticulum (SR) Ca METHOD: In mice diaphragms mechanically ventilated for short (6 h) and long (12 h) period, we assessed mitochondrial ROS production, mitochondrial aconitase activity as a marker of mitochondrial oxidative stress, RyR1 remodeling and function, Ca MEASUREMENTS AND MAIN RESULTS: 6 h of mechani...
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Diaphragm dysfunction and atrophy develop during controlled m...
Sustained ryanodine receptor (RyR) Ca <sup>2+</sup> leak is associated with pathological...
Background: Mechanical ventilation (MV) often leads to ventilation-induced diaphragm dysfunction (VI...
International audienceVentilator-induced diaphragm dysfunction (VIDD) increases morbidity and mortal...
Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occ...
International audienceRespiratory muscle contractile inactivity during mechanical ventilation (MV) i...
Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. Howev...
<div><p>Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failur...
Cytosolic phospholipase A2 (cPLA2) has been reported to be critical for infection-induced mitochondr...
Mechanical ventilation (MV) results in the rapid development of ventilator-induced diaphragm dysfunc...
International audienceAbstract Background To describe the effect of mechanical ventilation on diaphr...
Diaphragm dysfunction is prevalent in the progress of respiratory dysfunction in various critical il...
Mechanical ventilation (MV) is essential for patients with sepsis-related respiratory failure but ca...
International audienceThe diaphragm is a unique skeletal muscle designed to be rhythmically active t...
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Diaphragm dysfunction and atrophy develop during controlled m...
Sustained ryanodine receptor (RyR) Ca <sup>2+</sup> leak is associated with pathological...
Background: Mechanical ventilation (MV) often leads to ventilation-induced diaphragm dysfunction (VI...
International audienceVentilator-induced diaphragm dysfunction (VIDD) increases morbidity and mortal...
Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occ...
International audienceRespiratory muscle contractile inactivity during mechanical ventilation (MV) i...
Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. Howev...
<div><p>Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failur...
Cytosolic phospholipase A2 (cPLA2) has been reported to be critical for infection-induced mitochondr...
Mechanical ventilation (MV) results in the rapid development of ventilator-induced diaphragm dysfunc...
International audienceAbstract Background To describe the effect of mechanical ventilation on diaphr...
Diaphragm dysfunction is prevalent in the progress of respiratory dysfunction in various critical il...
Mechanical ventilation (MV) is essential for patients with sepsis-related respiratory failure but ca...
International audienceThe diaphragm is a unique skeletal muscle designed to be rhythmically active t...
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Diaphragm dysfunction and atrophy develop during controlled m...
Sustained ryanodine receptor (RyR) Ca <sup>2+</sup> leak is associated with pathological...
Background: Mechanical ventilation (MV) often leads to ventilation-induced diaphragm dysfunction (VI...