Assessment of cardiovascular risk by measuring omega-3 index in non-alcoholic fatty liver disease patients

Nealkoholna masna bolest jetre (NAFLD) najčešći je uzrok kroničnih bolesti jetre u zapadnim zemljama. Posljednjih desetak godina objavljen je veći broj studija koje govore o povezanosti NAFLD-a i kardiovaskularnih bolesti, a pokazalo se da su kardiovaskularne bolesti uz samu bolest jetre najčešći uzrok povećanog mortaliteta u bolesnika s NAFLD-om. Cilj ovog rada bio je procijeniti kardiovaskularni rizik 14 ispitanika oboljelih od NAFLD-a mjerenjem omega-3 indeksa, te odrediti postoji li korelacija omega-3 indeksa s ostalim pokazateljima kardiovaskularnog rizika - antropometrijskim parametrima, koncentracijom lipida u krvi, jetrenim enzimima i vrijednošću Indeksa masne jetre. Korištene su antropometrijske metode, ekstrakcija ukupnih lipida i plinska kromatografija. Rezultati procjene kardiovaskularnog rizika pokazuju da je omega-3 indeks kod ispitanika ţenskog spola bio 3,25 ± 1,14 %, dok je kod ispitanika muškog spola bio 3,74 ± 0,97 %. Dobivene vrijednosti su veoma male, te prema njima ispitanici oba spola spadaju u skupinu s velikim rizikom za razvoj kardiovaskularnih bolesti.Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries. Over the last decade, a number of studies has been published that indicate the association of NAFLD and cardiovascular disease. Cardiovascular disease with liver disease is the most common cause of increased mortality in patients with NAFLD. The aim of this thesis was to assess the cardiovascular risk of 14 patients with NAFLD by measuring the omega-3 index and to determine whether there is correlation of the omega-3 index with other indicators of cardiovascular risk - anthropometric parameters, lipid concentration in the blood, liver enzymes and the value of Fatty Liver Index. Anthropometric methods, total lipid extraction and gas chromatography were used. The results of cardiovascular risk assessment show that the omega-3 index in female subjects was 3.25 ± 1.14 %, while in male subjects it was 3.74 ± 0.97 %. The obtained values are very low, and according to them, both sexes belong to a group with a high risk of cardiovascular disease