OP147 SKELETAL MUSCLE FUNCTION DEFICITS AND DYSMOBILITY SYNDROME: ARE THESE TOOLS BETTER CHARACTERIZING PATIENTS WITH FRAGILITY FRACTURES?

Introduction: Fragility fractures have a huge impact on the healthcare management of elderly patients. These fractures are associated to impaired bone strength and functioning of skeletal muscle, and to characteristics and circumstances of falls. It is well known that muscle weakness has a pivotal role in determining falls. Recently have been proposed two new nosological entities, in order to identify functional limitation at an early stage: the dysmobility syndrome and the skeletal muscle function deficits (SMFD). These conditions are associated with an increased risk of fragility fractures. However, to the best of our knowledge, few studies investigated the association between osteoporotic fractures and dysmobility syndrome or SMFD. Purpose: The objective of this study was to evaluate the role of previous fragility fractures as risk factor for dysmobility syndrome and/or SMFD in post-menopausal women. Method: In this case–control study, we retrospectively examined data from the medical records of postmenopausal women aged 50 or older. We divided the study population in two groups. The first group includes women with a previous fragility fracture (cases) and the other group includes women without any previous osteoporotic fracture (controls). We identified the subjects with dysmobility syndrome, dynapenic SMFD, sarcopenic SMFD, and mixed SMFD, according to criteria proposed by Studenski et al. and Binkley et al.respectively, in both groups. Data collected refer to a 6-month period. Results: We retrieved data of 121 post-menopausal women, 77 (63.64 %) had already sustained a fragility fracture at any site (cases). The risk for dysmobility syndrome was significantly higher (adjusted OR for age and serum 25-OH vitamin D3 of 2.46) in the cases compared with the controls. Discussion and conclusions: Early diagnosis of conditions limiting mobility, including dysmobility syndrome and SMFD, in patients with a history of osteoporotic fracture could be useful to identify those who have a higher risk of new fragility fractures