Vaginal Misoprostol in Early Pregnancy Failure

Suguna R.Kumar
Vidya A Thobbi
Shafia Shafi

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Publication date

July 2010

Publisher

Al Ameen Medical College

Journal

issn:0974-1143

Abstract

Early pregnancy failure (EPF) occurs in 10-15% of clinically diagnosed pregnancies. 65% of these women are not willing for surgical evacuation. Medical evacuation is gaining acceptance as a treatment of option than surgical or expectant management. This is a prospective clinical trial of 150 pregnant women with EPF of <13weeeks gestation managed by 400µg of vaginal misoprostol 4hourly to a maximum of 3 doses. Failure to expel the products of conception in 24 hours, excessive bleeding per vagina and incomplete expulsion were managed by surgical evacuation. Complete and incomplete evacuation was confirmed by transvaginalsonography (TVS). All surgical evacuations done under I.V. sedation required no anesthesia because of the cervical priming e...