The insulin-like growth factor pathway, regulated by a complex interplay of growth factors, cognate receptors, and binding proteins, is critically important for many of the hallmarks of cancer such as oncogenesis, cell division, growth, and antineoplastic resistance. Naturally, a number of clinical trials have sought to directly abrogate insulin-like growth factor receptor 1 (IGF-1R) function and/or indirectly mitigate its downstream mediators such as mTOR, PI3K, MAPK, and others under the assumption that such therapeutic interventions would provide clinical benefit, demonstrable by impaired tumor growth as well as prolonged progression-free and overall survival for patients. Though a small subset of patients enrolled within phase I or II c...
4Over the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IG...
Insulin-like growth factors (IGFs) and insulin are main regulators of cell growth in human and in an...
Inhibition of the insulin-like growth factor 1 receptor (Igf1r) is an approach being taken in clinic...
The insulin-like growth factor pathway, regulated by a complex interplay of growth factors, cognate ...
Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in ca...
Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and...
Research conducted over the past two decades has shown the importance of the type 1 insulin-like gro...
Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations ...
The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and the I...
The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour o...
The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour o...
The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour o...
The insulin-like growth factor (IGF) system comprises multiple growth factor receptors, including in...
Insulin-like growth factor receptor 1 (IGF-1R) with its ligands and intracellular pathway is involve...
The insulin-like growth factors (IGEs; IGF-1 and IGF-2) play central roles in cell growth, different...
4Over the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IG...
Insulin-like growth factors (IGFs) and insulin are main regulators of cell growth in human and in an...
Inhibition of the insulin-like growth factor 1 receptor (Igf1r) is an approach being taken in clinic...
The insulin-like growth factor pathway, regulated by a complex interplay of growth factors, cognate ...
Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in ca...
Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and...
Research conducted over the past two decades has shown the importance of the type 1 insulin-like gro...
Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations ...
The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and the I...
The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour o...
The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour o...
The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour o...
The insulin-like growth factor (IGF) system comprises multiple growth factor receptors, including in...
Insulin-like growth factor receptor 1 (IGF-1R) with its ligands and intracellular pathway is involve...
The insulin-like growth factors (IGEs; IGF-1 and IGF-2) play central roles in cell growth, different...
4Over the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IG...
Insulin-like growth factors (IGFs) and insulin are main regulators of cell growth in human and in an...
Inhibition of the insulin-like growth factor 1 receptor (Igf1r) is an approach being taken in clinic...