Abstract Cancer remains a leading cause of death in the world today. Despite decades of research to identify novel therapeutic approaches, durable regressions of metastatic disease are still scanty and survival benefits often negligible. While the current strategy is mostly converging on target-therapies aimed at selectively affecting altered molecular pathways in tumor cells, evidences are in parallel pointing to cell metabolism as a potential Achilles' heel of cancer, to be disrupted for achieving therapeutic benefit. Critical differences in the metabolism of tumor versus normal cells, which include abnormal glycolysis, high lactic acid production, protons accumulation and reversed intra-extracellular pH gradients, make tumor site a hosti...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversedp...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversedp...
AbstractWith a projected 382.4 per 100,000 people expected to suffer from some form of malignant neo...
Cancer remains a leading cause of death in the world today. Despite decades of research to identify ...
Different research groups have recently described a proton [H(+)]-related mechanism underlying the i...
The rapid growth of cancer cells fueled by glycolysis produces large amounts of protons in cancer ce...
Although cancer is characterized by an intratumoral genetic heterogeneity, a totally deranged pH con...
AbstractAlthough cancer is characterized by an intratumoral genetic heterogeneity, a totally derange...
Although cancer is characterized by an intratumoral genetic heterogeneity, a totally deranged pH con...
Although cancer is characterized by an intratumoral genetic heterogeneity, a totally deranged pH con...
<div><p>The rapid growth of cancer cells fueled by glycolysis produces large amounts of protons in c...
Cancer cells acquire an unusual glycolytic behavior to a large extent relative to an intracellular a...
Cancer cells acquire an unusual glycolytic behavior to a large extent relative to an intracellular a...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed ...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed ...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversedp...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversedp...
AbstractWith a projected 382.4 per 100,000 people expected to suffer from some form of malignant neo...
Cancer remains a leading cause of death in the world today. Despite decades of research to identify ...
Different research groups have recently described a proton [H(+)]-related mechanism underlying the i...
The rapid growth of cancer cells fueled by glycolysis produces large amounts of protons in cancer ce...
Although cancer is characterized by an intratumoral genetic heterogeneity, a totally deranged pH con...
AbstractAlthough cancer is characterized by an intratumoral genetic heterogeneity, a totally derange...
Although cancer is characterized by an intratumoral genetic heterogeneity, a totally deranged pH con...
Although cancer is characterized by an intratumoral genetic heterogeneity, a totally deranged pH con...
<div><p>The rapid growth of cancer cells fueled by glycolysis produces large amounts of protons in c...
Cancer cells acquire an unusual glycolytic behavior to a large extent relative to an intracellular a...
Cancer cells acquire an unusual glycolytic behavior to a large extent relative to an intracellular a...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed ...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed ...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversedp...
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversedp...
AbstractWith a projected 382.4 per 100,000 people expected to suffer from some form of malignant neo...