Propolis attenuates oxidative injury in brain and lung of nitric oxide synthase inhibited rats

Background: The blocking of nitric oxide synthase (NOS) activity may reason vasoconstriction with formation of reactive oxygen species. Propolis has biological and pharmacological properties, such as antioxidant. The aim of this study was to examine the antioxidant effects of propolis which natural product on biochemical parameters in brain and lung tissues of acute nitric oxide synthase inhibited rats by Nω-nitro-L-arginine methyl ester (L-NAME). Methods: Rats have been received L-NAME (40 mg/kg, intraperitoneally), NOS inhibitor for 15 days to produce hypertension and propolis (200mg/kg, by gavage) the lastest 5 of 15 days. Results: There were the increase (P<0.001) in the malondialdehyde levels in the L-NAME treatment groups when compared to control rats, but the decrease (P<0.001) in the catalase activities in both brain and lung tissues. There were statistically changes (P