Abstract Background Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein synthesis. Insulin also increases the rate of translation but does not promote overt cardiomyocyte hypertrophy. One mechanism of translational regulation is through 5' terminal oligopyrimidine tracts (TOPs) that, in response to growth stimuli, promote mRNA recruitment to polysomes for increased translation. TOP mRNAs include those encoding ribosomal proteins, but the full panoply remains to be established. Here, we used microarrays to compare the effects of endothelin-1 and insulin on ...
Abstract Background Cardiac cell fate specification occurs through progressive steps, and its gene e...
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regula...
Titin, a giant sarcomeric protein, is largely responsible for the diastolic properties of the hea...
Background: Changes in cellular phenotype result from underlying changes in mRNA transcription and t...
Background: Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividin...
Summary: Regulation of gene expression is an important aspect of insulin action but in vivo is inter...
BACKGROUND: In diabetes chronic hyperinsulinemia contributes to the instability of the atherosclerot...
BACKGROUND: In diabetes chronic hyperinsulinemia contributes to the instability of the atherosclero...
Apolipoprotein B (ApoB) synthesis is partially regulated at the translational level; however, the mo...
Background: In diabetes chronic hyperinsulinemia contributes to the instability of the atherosclerot...
Regulation of gene expression is an important aspect of insulin action but in vivo is intertwined wi...
Heart disease remains the leading cause of death in the United States. Despite what is known about t...
Elevated protein synthesis is a fundamental mechanism contributing to a growing heart, during which ...
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regula...
Proud. Activation of mRNA translation in rat cardiac myo-cytes by insulin involves multiple rapamyci...
Abstract Background Cardiac cell fate specification occurs through progressive steps, and its gene e...
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regula...
Titin, a giant sarcomeric protein, is largely responsible for the diastolic properties of the hea...
Background: Changes in cellular phenotype result from underlying changes in mRNA transcription and t...
Background: Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividin...
Summary: Regulation of gene expression is an important aspect of insulin action but in vivo is inter...
BACKGROUND: In diabetes chronic hyperinsulinemia contributes to the instability of the atherosclerot...
BACKGROUND: In diabetes chronic hyperinsulinemia contributes to the instability of the atherosclero...
Apolipoprotein B (ApoB) synthesis is partially regulated at the translational level; however, the mo...
Background: In diabetes chronic hyperinsulinemia contributes to the instability of the atherosclerot...
Regulation of gene expression is an important aspect of insulin action but in vivo is intertwined wi...
Heart disease remains the leading cause of death in the United States. Despite what is known about t...
Elevated protein synthesis is a fundamental mechanism contributing to a growing heart, during which ...
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regula...
Proud. Activation of mRNA translation in rat cardiac myo-cytes by insulin involves multiple rapamyci...
Abstract Background Cardiac cell fate specification occurs through progressive steps, and its gene e...
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regula...
Titin, a giant sarcomeric protein, is largely responsible for the diastolic properties of the hea...