Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs). Here, we extend our analyses to the contribution of CRASP-4 in mediating complement resistance of B. burgdorferi and its interaction with human complement regulators. CRASP-4 (also known as ErpC) was immobilized onto magnetic beads and used to capture proteins from human serum. Following Western blotting, factor H (CFH), CFH-related protein 1 (CFHR1), CFHR2, and CFHR5 were identified as ligands of CRASP-4. To analyze the impact of native CRASP-4 on mediating survival of serum-sensitive cells in human serum, a B. garinii strain was generated that ectopically expresses CRA...
Complement regulator-acquiring surface protein 1 (CRASP-1) is the dominant factor-H-like protein 1 (...
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved stra...
The complement regulator-acquiring surface protein (CRASP)-1 is a member of the paralogous gene fami...
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators th...
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators th...
Background: One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in ...
Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. S...
One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular t...
ABSTRACT In order to survive and persist in an immunocompetent human host, Borrelia burgdorferi cont...
ABSTRACT In order to survive and persist in an immunocompetent human host, Borrelia burgdorferi cont...
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance...
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transm...
The etiologic agent of Lyme disease, Borrelia burgdorferi, is capable of circumventing the immune de...
Citation: Garcia, B. L., Zhi, H., Wager, B., Hook, M., & Skare, J. T. (2016). Borrelia burgdorferi B...
The complement system is an organized proteolytic cascade of dozens of proteins that functions in th...
Complement regulator-acquiring surface protein 1 (CRASP-1) is the dominant factor-H-like protein 1 (...
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved stra...
The complement regulator-acquiring surface protein (CRASP)-1 is a member of the paralogous gene fami...
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators th...
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators th...
Background: One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in ...
Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. S...
One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular t...
ABSTRACT In order to survive and persist in an immunocompetent human host, Borrelia burgdorferi cont...
ABSTRACT In order to survive and persist in an immunocompetent human host, Borrelia burgdorferi cont...
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance...
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transm...
The etiologic agent of Lyme disease, Borrelia burgdorferi, is capable of circumventing the immune de...
Citation: Garcia, B. L., Zhi, H., Wager, B., Hook, M., & Skare, J. T. (2016). Borrelia burgdorferi B...
The complement system is an organized proteolytic cascade of dozens of proteins that functions in th...
Complement regulator-acquiring surface protein 1 (CRASP-1) is the dominant factor-H-like protein 1 (...
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved stra...
The complement regulator-acquiring surface protein (CRASP)-1 is a member of the paralogous gene fami...