This study examined the contributions of the primary and secondary motor cortices (M1 and M2) to action differentiation and sequencing in mice. In Experiment 1, mice with excitotoxic lesions of M1 and M2 and sham controls learned to emit lever presses exceeding a criterion duration to earn food rewards. Duration differentiation obeys Weber’s law—i.e. the spread of the distribution is proportional to the average duration. M1 or M2 lesions did not affect differentiation of press durations. Experiment 2 studied the effects of the same lesions on the learning of a simple sequence consisting of two lever presses, one distal, and the other proximal, to the reward. M2 lesions impaired the acquisition and reversal of this sequence. ...
155 pagesMotor sequences are constructed from primitives, hypothesized building blocks of movement, ...
Understanding the nature and consequences of information flow between the basal ganglia, cerebellum,...
International audienceWhisker-guided decision making in mice is thought to critically depend on info...
AbstractBackground: Motor skill learning usually comprises “fast” improvement in performance within ...
The generation of voluntary movements can be described as a sequence of neuronal processes, includin...
The ability to use information from ones prior actions is necessary for decision-making. While orbit...
Mammalian motor cortex consists of several interconnected subregions thought to play distinct roles ...
Producing movements is a fundamental output of the brain. Over many millennia the brain has undergon...
Animals face the dilemma between exploiting known opportunities and exploring new ones, a decision-m...
SummaryThe serial ordering of individual movements into sequential patterns is thought to require sy...
Basal ganglia stroke is often associated with functional deficits in patients, including difficultie...
Motor cortical neurons exhibit persistent selective activities (selectivity) during motor planning. ...
<p>(A) The laser is turned on (50 Hz) as long as the mice (<i>n</i> = 4) hold down the lever. (B) Pr...
The mediodorsal thalamus (MD) is a crucial component of the neural network involved in the learning ...
Anterior lateral motor cortex (ALM) in the mouse is involved in the formation and retention of futur...
155 pagesMotor sequences are constructed from primitives, hypothesized building blocks of movement, ...
Understanding the nature and consequences of information flow between the basal ganglia, cerebellum,...
International audienceWhisker-guided decision making in mice is thought to critically depend on info...
AbstractBackground: Motor skill learning usually comprises “fast” improvement in performance within ...
The generation of voluntary movements can be described as a sequence of neuronal processes, includin...
The ability to use information from ones prior actions is necessary for decision-making. While orbit...
Mammalian motor cortex consists of several interconnected subregions thought to play distinct roles ...
Producing movements is a fundamental output of the brain. Over many millennia the brain has undergon...
Animals face the dilemma between exploiting known opportunities and exploring new ones, a decision-m...
SummaryThe serial ordering of individual movements into sequential patterns is thought to require sy...
Basal ganglia stroke is often associated with functional deficits in patients, including difficultie...
Motor cortical neurons exhibit persistent selective activities (selectivity) during motor planning. ...
<p>(A) The laser is turned on (50 Hz) as long as the mice (<i>n</i> = 4) hold down the lever. (B) Pr...
The mediodorsal thalamus (MD) is a crucial component of the neural network involved in the learning ...
Anterior lateral motor cortex (ALM) in the mouse is involved in the formation and retention of futur...
155 pagesMotor sequences are constructed from primitives, hypothesized building blocks of movement, ...
Understanding the nature and consequences of information flow between the basal ganglia, cerebellum,...
International audienceWhisker-guided decision making in mice is thought to critically depend on info...