The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: A better local profile in pleural fluid

D'attilio, Luciano David
Díaz, Ariana
Fernández, Rocío del Valle
Bongiovanni, Bettina
Santucci, Natalia Estefanía
Dídoli, Griselda
Lioi, Susana
Gardeñez, W.
Naninni, J. L.
Del Rey, A.
Besedovsky, H.
Bottasso, Oscar Adelmo
Bay, Maria Luisa

Open link

Publication date

March 2018

DOI

10.5588/ijtld.17.0270

Publisher

International Union Against Tuberculosis and Lung Disease

Journal

The International Journal of Tuberculosis and Lung Disease

Abstract

BACKGROUND: Tuberculosis (TB) is a major health problem worldwide. In TB, the immune and central nervous systems modulate each other. The two main components of this network are the hypothalamic-pituitary-adrenal axis (HPA) and autonomic nervous system (ANS). OBJECTIVE: To elucidate neuro-endocrine-immune (NEI) interactions in pulmonary (PTB) or pleural (PLTB) TB, we analysed the relationship among compounds from these systems. METHODS: We quantified levels of catecholamines, hormones and cytokines in plasma from patients with PTB (n = 46) or PLTB (n = 12) and controls (n = 32), and in the pleural fluid from PLTB patients. Transcript expression for genes involved in glucocorticoid-related function (quantitative real-time polymerase chain re...