Acute myeloid leukemia (AML), the most common acute leukemia in adults, is a heterogeneous malignant clonal disorder arising from multipotent hematopoietic progenitor cells characterized by genetic and concerted epigenetic aberrations. Core binding factor-Leukemia (CBFL) is characterized by the recurrent reciprocal translocations t(8;21)(q22;q22) or inv(16)(p13;q22) that, expressing the distinctive RUNX1-RUNX1T1 (also known as Acute myeloid leukemia1-eight twenty-one, AML1-ETO or RUNX1/ETO) or CBFB-MYH11 (also known as CBF\u3b2-SMMHC) translocation product respectively, disrupt the essential hematopoietic function of the CBF. In the past decade, remarkable progress has been achieved in understanding the structure, three-dimensional (3D) chr...
The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors alpha (CB...
Recurrent chromosomal rearrangements are associated with the development of acute myeloid leukemia (...
RUNX1, also known as CBFa, is a master regulator of haematopoiesis. In Acute Myeloid Leukaemia (AML)...
Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently defined by recu...
Leukemia is a hematopoietic cancer that is characterized by the abnormal differentiation and prolife...
The gene encoding for core-binding factor beta (CBFbeta) is altered in acute myeloid leukemia sample...
AbstractCore-binding factor leukemia (CBFL) is a subgroup of acutemyeloid leukemia (AML) characteriz...
Chromosomal translocations are one of the hallmarks of acute myeloid leukemia (AML), often leading t...
AbstractThe inv(16) translocation is associated with 5% of AML cases and gives rise to expression of...
The core binding factor (CBF) transcription factor complex is involved in the regulation of a number...
The AML1/Runx1 transcription factor and its heterodimerization partner CBFβ are essential regulators...
Dysregulated gene expression contributes to most prevalent features in human cancers. Here, we show ...
<div><p>The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors a...
with the CBFb protein. This complex is known as core binding factor (CBF), and embryonic lethality d...
SummaryDominant RUNX1 inhibition has been proposed as a common pathway for CBF leukemia. CBFβ-SMMHC,...
The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors alpha (CB...
Recurrent chromosomal rearrangements are associated with the development of acute myeloid leukemia (...
RUNX1, also known as CBFa, is a master regulator of haematopoiesis. In Acute Myeloid Leukaemia (AML)...
Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently defined by recu...
Leukemia is a hematopoietic cancer that is characterized by the abnormal differentiation and prolife...
The gene encoding for core-binding factor beta (CBFbeta) is altered in acute myeloid leukemia sample...
AbstractCore-binding factor leukemia (CBFL) is a subgroup of acutemyeloid leukemia (AML) characteriz...
Chromosomal translocations are one of the hallmarks of acute myeloid leukemia (AML), often leading t...
AbstractThe inv(16) translocation is associated with 5% of AML cases and gives rise to expression of...
The core binding factor (CBF) transcription factor complex is involved in the regulation of a number...
The AML1/Runx1 transcription factor and its heterodimerization partner CBFβ are essential regulators...
Dysregulated gene expression contributes to most prevalent features in human cancers. Here, we show ...
<div><p>The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors a...
with the CBFb protein. This complex is known as core binding factor (CBF), and embryonic lethality d...
SummaryDominant RUNX1 inhibition has been proposed as a common pathway for CBF leukemia. CBFβ-SMMHC,...
The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors alpha (CB...
Recurrent chromosomal rearrangements are associated with the development of acute myeloid leukemia (...
RUNX1, also known as CBFa, is a master regulator of haematopoiesis. In Acute Myeloid Leukaemia (AML)...