Add to ORKGDrug discovery is a long and expensive process, whose efficiency is often limited due to the poor predictivity of in vitro models currently exploited in the pre-clinical phases. Among others, cardiac toxicity represents a prevalent adverse effect preventing the drug to reach the market. Here we present a new beating heart-on-chip platform able to generate functional 3D human cardiac microtissues, whose electrophysiological signals can be directly extracted during culture by means of an integrated electrical measurement system. Hence, the proposed microfluidic platform represents a powerful pre-clinical cardiac model to screen the cardiotoxic effects of new compounds
The emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue mod...
Drug development continuously faces challenges in efficiently predicting toxicity and verifying effi...
The high death toll of cardiovascular diseases worldwide and the lack of effective treatments for th...
Drug discovery is a long and expensive process, whose efficiency is often limited due to the poor pr...
Cardiac toxicity still represents a common adverse outcome causing drug attrition and post-marketing...
As cardiac diseases are one of the main causes of death worldwide, research on better understanding ...
With the increasing attention on cardiovascular disorders and the current inability of pre-clinical ...
Modeling human cardiac tissues in vitro is essential to elucidate the biological mechanisms related ...
In the past few years, microfluidic-based technology has developed microscale models recapitulating ...
Animal models and traditional cell cultures are essential tools for drug development. However, these...
We present the development of three-dimensional cardiac tissues within a microfluidic device with th...
Organs-on-chip technology has recently emerged as a promising tool to generate advanced cardiac tiss...
The emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue mod...
Drug development continuously faces challenges in efficiently predicting toxicity and verifying effi...
The high death toll of cardiovascular diseases worldwide and the lack of effective treatments for th...
Drug discovery is a long and expensive process, whose efficiency is often limited due to the poor pr...
Cardiac toxicity still represents a common adverse outcome causing drug attrition and post-marketing...
As cardiac diseases are one of the main causes of death worldwide, research on better understanding ...
With the increasing attention on cardiovascular disorders and the current inability of pre-clinical ...
Modeling human cardiac tissues in vitro is essential to elucidate the biological mechanisms related ...
In the past few years, microfluidic-based technology has developed microscale models recapitulating ...
Animal models and traditional cell cultures are essential tools for drug development. However, these...
We present the development of three-dimensional cardiac tissues within a microfluidic device with th...
Organs-on-chip technology has recently emerged as a promising tool to generate advanced cardiac tiss...
The emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue mod...
Drug development continuously faces challenges in efficiently predicting toxicity and verifying effi...
The high death toll of cardiovascular diseases worldwide and the lack of effective treatments for th...