Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage
- Anderson, C
- Heeley, E
- Huang, Y
- Wang, J
- Stapf, C
- Delcourt, C
- Lindley, R
- Robinson, T
- Lavados, P
- Neal, B
- Hata, J
- Arima, H
- Parsons, M
- Li, Y
- Wang, J
- Heritier, S
- Li, Q
- Woodward, M
- Simes, J
- Davis, SM
- Chalmers, J
DOIAbstract
BACKGROUND: Whether rapid lowering of elevated blood pressure would improve the outcome in patients with intracerebral hemorrhage is not known. METHODS: We randomly assigned 2839 patients who had had a spontaneous intracerebral hemorrhage within the previous 6 hours and who had elevated systolic blood pressure to receive intensive treatment to lower their blood pressure (with a target systolic level of <140 mm Hg within 1 hour) or guideline-recommended treatment (with a target systolic level of <180 mm Hg) with the use of agents of the physician's choosing. The primary outcome was death or major disability, which was defined as a score of 3 to 6 on the modified Rankin scale (in which a score of 0 indicates no symptoms, a score of 5 indicate...
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