Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions
- Renault, Yohann J. G.
- Lynch, Rosemary
- Marelli, Enrico
- Sharma, Sunil, V
- Pubill-Ulldemolins, Cristina
- Sharp, Joshua A.
- Cartmell, Christopher
- Cárdenas, Paco
- Goss, Rebecca J. M.
DOIAbstract
Blending synthetic biology and synthetic chemistry represents a powerful approach to diversity complex molecules. To further enable this, compatible synthetic tools are needed. We report the first Buchwald Hartwig amination reactions with unprotected halo-tryptophans under aqueous conditions and demonstrate this methodology is applicable also to the modification of unprotected tripeptides and the natural product barettin
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