Abstract There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet unexpected drought in new drug development across the spectrum. In this commentary, the sources of this dilemma and potential avenues to redress the issue are explored. These include a critical review of diagnostic issues and of selection of participants for clinical trials, and the mechanisms for identifying new drugs and new drug targets. Historically, the vast majority of agents have been discovered serendipitously or have been modifications of existing agents. Serendipitous discoveries, based on astute clinical observation or data mining, remain a valid option, as is illustrated by the suggestion in the paper by Wahlqvist and coll...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
Numerous novel neuroscience-based drug targets have been identified in recent years. However, it rem...
There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet u...
There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet u...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
AbstractThere are many new advances in neuroscience and mental health which should lead to a greater...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
Numerous novel neuroscience-based drug targets have been identified in recent years. However, it rem...
There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet u...
There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet u...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability...
AbstractThere are many new advances in neuroscience and mental health which should lead to a greater...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
There are many new advances in neuroscience and mental health which should lead to a greater underst...
Numerous novel neuroscience-based drug targets have been identified in recent years. However, it rem...