HOW DO VITAMIN AND PLANT SEEDS WORK AS HYPOLIPIDEMIC AGENTS ?

Objectives: Cardiovascular diseases are leading cause of death in western and eastern countries of the world. Hyperlipidemia is one of the strong risk fractions for heart diseases. Purpose of current study was to estimate Kalonji and vitamin B-3 affects on LDL-cholesterol. Methods: To evaluate hypolipidemic drugs efficacy, the study was conducted at National hospital, Lahore Pakistan from January 2016 to August 2016. Ninety hyperlipidemic patients were selected from cardiology and medical wards of the hospital. They were divided in three groups, one at placebo therapy, another on Kalonji and third one on Vitamin B3. Results: After one and half month, significant changes (p value ranging from <0.05 to <0.001) were observed in their LDL and HDL-cholesterol. Conclusion of the study was to recommend use of herbal medicine and vitamin B3 for prevention of any heart diseases with good patient compliance. Conclusion: Study concludes that Kalonji and vitamin B-3 affects LDL-cholesterol potently and these hypolipidemic agents increase HDL-cholesterol moderately. Peer Review History: Received 1 November 2017; Revised 5 December; Accepted 29 December, Available online 15 January 2018 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indonesia, ahmad.najib@umi.ac.id Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Hebatalla Ibrahim Ahmed Abdel Hameed, Al-Azhar University, Faculty of Pharmacy (Girls), Nasr City, Cairo, Egypt, hebatalla123@yahoo.com Ahmed Tagelsir Mohamed Ali, National University, Sudan, ahmedtagelsir7@hotmail.com Similar Articles: USE OF DIOSGENIN, YAMOGENIN, TIGOGENIN AND NEOTIGOGENIN FOR TREATMENT OF HYPERLIPIDEMIA BY INHIBITING CHOLESTEROL ABSORPTION IN GI