DEVELOPMENT AND EVALUATION OF ALBENDAZOLE MICROCAPSULE FOR COLONIC DRUG DELIVERY SYSTEM

Objective: Albendazole is a benzimidazole carbamate broad spectrum oral anthelmetic drug. It is poorly water soluble and it undergoes extensive metabolism in the intestine and liver. Objective of present study was to prepare and evaluate microcapsule of Albendazole for colonic delivery. Methods: Six batches of Albendazole microcapsules were prepared using different concentration of polymers like Eudragit RS-100, chitosan, HPMC by solvent evaporation method. The microcapsules were then evaluated for micromeritic properties, percentage yield, incorporation efficiency, drug content. In vitro dissolution profile of each formulation was determined by employing USP XXIII rotating basket method. Results: The drug content was found to be very high in all formulations, incorporation efficiency was found to be good in all formulations. Highest incorporation efficiency 96.48 % was found in batch of MC6. Maximum drug release was shown by microcapsules formulation of batch MC6 (90.18%) Conclusion: Study concludes that Albendazole microcapsules may prove to be potential candidate for safe and effective sustained drug delivery. Peer Review History: Received 19 February 2017; Revised 11 March; Accepted 21 April, Available online 15 May 2017 Academic Editor: Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, alyahawipharm@yahoo.com Received file: Reviewer's Comments: Average Peer review marks at initial stage: 3.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Mohamed Salama, Modern University for Technology & Information, Egypt, salama47@yahoo.com Dr. Hasniza Zaman Huri, University of Malaya Medical Centre, Kuala Lumpur, hasnizazh@ummc.edu.my Similar Articles: COLON SPECIFIC DRUG DELIVERY SYSTEMS: CURRENT TRENDS AND APPROACHES FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS CONTAINING EXTRACT OF SOLENOSTEMMA ARGEL (HARGEL