Cryoglobulinemia in the course of a primary Sjögren’s syndrome

A 58-year-old woman with primary Sjögren’s syn­drome (pSS), peripheral neuropathy and positive serum cryoglobulin was admitted for evaluation of purpura on her skin. Cryoglobulinemic vasculitis was diagnosed based on clinical and laboratory find­ings . There was no response to cyclophosphamide pulse therapy, steroid therapy and cyclosporine. We presente the discussion about cryoglobulinemic vasculitis in pSS, the overall prognosis (B-cell lym­phomas) and differential diagnosis