About 2 percent of developed countries population use vitamin K antagonists (VKA), such as warfarin.These anticoagulation drugs are commonly prescribed for the purpose of thromboembolism prevention,in cases of atrial fibrillation, mechanical heart valves, deep vein thrombosis, pulmonary embolism andetc. The frequency of VKA prescription is massively increasing in the whole world. The main reason forit is the ageing of the population. As the usage of anticoagulants is increasing, doctors more often getto encounter patients with gastrointestinal bleeding taking anticoagulating drugs. The treatment of thesepatients is difficult because there are several important factors that have to be considered while choosingthe tactic of treatment, such as...