Abstract The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS). In the present study, we determinate pDCs levels by flow cytometry in Cerebrospinal Fluid (CSF) and Peripheral Blood from MS patients in relapsing and in remitting phases of the disease, comparing with other non-inflammatory diseases (OND). We provide evidence that MS patients in relapse without any treatment have a significantly (p < 0.01) higher percentage of pDCs in CSF than do patients in remission or those with OND. No change in ...
Background: High content immune profiling in peripheral blood may reflect immune aberrations associa...
<div><p>Interferon-β is an established treatment for patients with multiple sclerosis (MS) but its m...
Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflam...
The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which ...
Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nerv...
The roles of plasmacytoid dendritic cells (pDCs) and their response to interferon (IFN)-beta therapy...
The roles of plasmacytoid dendritic cells (pDCs) and their response to interferon (IFN)-beta therapy...
Recent evidence emphasises a pivotal role for dendritic cells (DC) in the control of immunity by pri...
Multiple sclerosis (MS) is characterised by chronic inflammation in the central nervous system (CNS)...
Introduction Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central ne...
Objective We hypothesized that autoaggressive immune responses observed in multiple sclerosis (MS)...
Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by persiste...
Thirty-nine patients with clinically definite multiple sclerosis (MS) entered the study. Of 28 subje...
<p>Frequency of myeloid and plasmacytoid dendritic cells (MDCs and PDCs) was determined in frozen ce...
<p>Frequency of plasmacytoid dendritic cells (PDCs) expressing TLR9 (A), HLA-DR (B), and CCR7 (C) in...
Background: High content immune profiling in peripheral blood may reflect immune aberrations associa...
<div><p>Interferon-β is an established treatment for patients with multiple sclerosis (MS) but its m...
Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflam...
The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which ...
Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nerv...
The roles of plasmacytoid dendritic cells (pDCs) and their response to interferon (IFN)-beta therapy...
The roles of plasmacytoid dendritic cells (pDCs) and their response to interferon (IFN)-beta therapy...
Recent evidence emphasises a pivotal role for dendritic cells (DC) in the control of immunity by pri...
Multiple sclerosis (MS) is characterised by chronic inflammation in the central nervous system (CNS)...
Introduction Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central ne...
Objective We hypothesized that autoaggressive immune responses observed in multiple sclerosis (MS)...
Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by persiste...
Thirty-nine patients with clinically definite multiple sclerosis (MS) entered the study. Of 28 subje...
<p>Frequency of myeloid and plasmacytoid dendritic cells (MDCs and PDCs) was determined in frozen ce...
<p>Frequency of plasmacytoid dendritic cells (PDCs) expressing TLR9 (A), HLA-DR (B), and CCR7 (C) in...
Background: High content immune profiling in peripheral blood may reflect immune aberrations associa...
<div><p>Interferon-β is an established treatment for patients with multiple sclerosis (MS) but its m...
Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflam...