Systemic radionuclide therapy with Samarium-153-EDTMP for painful bone metastases

METHODS: We introduced in 33 patients intravenous systemic administration of Samarium-153-EDTMP. Average age of patients was 61 years, range from 29 to 83 years. Mean application activity was 39 MBq per kg of patient´s body weight. RESULTS: One month after this administration we observed a significant analgetic effect in 37% of patients, partial analgetic effect in 37% and we noticed no effect in 26% of patients. Three months after administration we observed a significant analgetic effect in 45% of patients, a partial effect in 26% and no effect in 29% of patients. The withdrawal of bone pain was joined with an improvement of the patient´s mobility and with the decrease of the necessary dose of anodynes and nonsteroid analgetics