Systemic treatments for advanced cutaneous melanoma — Cochrane Systematic Review 2018

The results of the systematic review have the leading place in the hierarchy of clinical data reliability. They allow to extend the conclusions from individual studies to a larger population, minimizing the risk of systematic errors. Meta-analysis is the final step of the review of enough homogenous primary research that allow to quantitatively synthesize their results. In 2018, the Cochrane systematic review and data meta-analysis which assessed the effects of various systemic treatments of metastatic cutaneous melanoma were published. All relevant trials published up to October 2017 were included. This article introduces the assumptions of the meta-analysis and presents its results regarding the effectiveness of the most important systemic treatments of melanoma