Bipolar disorder is a mood disorder for which the development of new treatments has been hindered by the lack of a reliable animal model. Previous studies in our lab have shown that daily injection of early postnatal rat pups with homocysteic acid (HCA), a homocysteine metabolite, leads to a mixed manic/depressive phenotype in adulthood. These results suggest that early HCA exposure may serve as a good model for bipolar disorder. To test the predictive validity of this model, we sought to determine if treatment of HCA-exposed animals with lithium was effective in reducing mixed manic/depressive behaviors elicited by HCA. As predicted, lithium treatment resulted in diminished manic-like behaviors in the HCA-treated rats and restored spatial ...
This research investigated the effects of different doses of lithium on rats' behavior in an attempt...
1. 1. Adult male Sprague Dawley rats were given lithium as a dietary supplement, or a control diet.2...
The effect of lithium administration on the learned helplessness model of depression was investigate...
The development of novel treatments for Bipolar Disorder has been hampered by the lack of a good ani...
Previous work in our laboratory has shown that demonstrated that male and female rats that receive d...
Bipolar disorder is a neuropsychiatric disease characterized by cyclical fluctuations of mood states...
17 p.Bipolar disorder (BPD) is a devastating long-term disease for which a significant symptom is ma...
Homocysteic acid (HCA), a NMDA receptor agonist, is an endogenous compound formed from the oxidation...
Caloric intake reduction has been considered as the major experimental manipulation able to increase...
Alterations in brainstem circuits have been proposed as a possible mechanism underlying the etiology...
Evaluate the efficacy of folic acid (FA) as a therapeutic adjunct to lithium (Li) on the manic-like ...
Lithium is an effective treatment for bipolar disorder (BD) as it reduces the occurrence of mania, w...
International audienceSeverity of lithium poisoning depends on the ingested dose, previous treatment...
Objectives: The goal of the present study was to investigate the effects of lithium administration ...
Homocysteic acid (HCA), a NMDA receptor agonist, is an endogenous metabolite formed from the oxidati...
This research investigated the effects of different doses of lithium on rats' behavior in an attempt...
1. 1. Adult male Sprague Dawley rats were given lithium as a dietary supplement, or a control diet.2...
The effect of lithium administration on the learned helplessness model of depression was investigate...
The development of novel treatments for Bipolar Disorder has been hampered by the lack of a good ani...
Previous work in our laboratory has shown that demonstrated that male and female rats that receive d...
Bipolar disorder is a neuropsychiatric disease characterized by cyclical fluctuations of mood states...
17 p.Bipolar disorder (BPD) is a devastating long-term disease for which a significant symptom is ma...
Homocysteic acid (HCA), a NMDA receptor agonist, is an endogenous compound formed from the oxidation...
Caloric intake reduction has been considered as the major experimental manipulation able to increase...
Alterations in brainstem circuits have been proposed as a possible mechanism underlying the etiology...
Evaluate the efficacy of folic acid (FA) as a therapeutic adjunct to lithium (Li) on the manic-like ...
Lithium is an effective treatment for bipolar disorder (BD) as it reduces the occurrence of mania, w...
International audienceSeverity of lithium poisoning depends on the ingested dose, previous treatment...
Objectives: The goal of the present study was to investigate the effects of lithium administration ...
Homocysteic acid (HCA), a NMDA receptor agonist, is an endogenous metabolite formed from the oxidati...
This research investigated the effects of different doses of lithium on rats' behavior in an attempt...
1. 1. Adult male Sprague Dawley rats were given lithium as a dietary supplement, or a control diet.2...
The effect of lithium administration on the learned helplessness model of depression was investigate...