The controversy over imageless thought versus picture thinking (especially via mechanical models), with the recent reconsideration of model-based reasoning in the physical sciences is briefly examined. The main focus of the article is on the role of instrumentally elicited images (scopic instruments, cameras, CCDs) in the sciences, especially in the physical sciences, with special reference to optics, experimental particle physics and observational astronomy, against the background of the civilization of digital images, though to some degree every scientific discipline is implicated. Imaging, today chiefly in the mode of electronic digital visual imaging, reaches into every phase of scientific inquiry, observational, experimental, simulatio...