The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis
- M. Tarrants
- M. Oleen-Burkey
- J. Castelli-Haley
- M. J. Lage
DOIAbstract
Objective. Examine the impact of comorbid depression on adherence to disease-modifying therapy (DMT) for multiple sclerosis (MS). Methods. A retrospective database was used to identify patients with MS treated with a DMT. Patients with MS and comorbid depression were matched to patients with MS only. Adherence to DMT was proxied by the medication possession ratio (MPR) and multivariate regressions were used to examine the association between comorbid depression and adherence to DMT. Results. Patients with comorbid depression had a 10 point lower MPR (P<0.01) and were less likely to achieve a MPR of at least 80% (odds ratio (OR)=0.55; 95% confidence interval (CI) 0.42–0.74) than those without depression. While treatment with an antidepressan...
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