Effects of Ascorbic Acid, Protein and Lead on the Anemic Guinea Pigs.

To clarify the effects of ascorbic acid, protein and lead on the anemia of guinea pigs, following experiments were carried out. 1) NADPH-Cytochrome C reductase is a limiting enzyme of drug metabolizing system in liver microsome. Activity of the enzyme was inhibited not by protein or ascorbic acid, but by lead. 2) δAminolevulinic acid synthetase was activated compensatively by lead administration, ascorbic acid deficiency and low protein diet intake. 3) δ-Aminolevulinic acid dehydratase activity was inhibited severely by the administration of lead and mildly by the deficiency of ascorbic acid. From these findings, author concludes that the healing mechanism of protein in lead poisoned anemia is different from that of ascorbic acid. The simultaneous administration of high protein diet and ascorbic acid is very effective to the lead poisoned anemia.10KJ00004311040論文Articledepartmental bulletin pape